The landscape of different molecular modules in an immune microenvironment during tuberculosis infection

• DOI: 10.1093/bib/bbab071
• Publication Date: 2021-02-18T12:36:05Z
• Authors: Nan Zhang; Xizi Luo; JuanJuan Huang; Hongyan Song; Xinyue Zhang; Honglan Huang; Shishun Zhao; Guoqing Wang
• Keywords: 0301 basic medicine; 0303 health sciences; Computational Biology; Endothelial Cells; Epithelial Cells; Mycobacterium tuberculosis; Immunity, Innate; Mucosal-Associated Invariant T Cells; 3. Good health; Killer Cells, Natural; 03 medical and health sciences; Gene Expression Regulation; Cyclooxygenase 2; Host-Pathogen Interactions; Macrophages, Alveolar; Humans; Natural Killer T-Cells; Tuberculosis; Cell Adhesion Molecules; Chemokines, CXC; Intraepithelial Lymphocytes; Lung; Algorithms

Tuberculosis is a chronic inflammatory disease caused by Mycobacterium tuberculosis. When tuberculosis invades the human body, innate immunity first line of defense. However, how immune microenvironment responds remains unclear. In this research, we studied function each type cell and explained principle an microenvironment. Based on differences in microenvironment, modularized analysis response five cells two structural cells. The results showed that stress response, genes CXCL3, PTGS2 TNFAIP6 regulated nuclear factor kappa B(NK-KB) pathway played crucial role fighting against active algorithm, metabolic heterogeneity. Besides, after infection, chemotactic effect based co-expression immunoregulatory module.