meta-MEME: Motif-based hidden Markov models of protein families

• DOI: 10.1093/bioinformatics/13.4.397
• Publication Date: 2007-01-13T16:51:47Z
• Authors: William N. Grundy; Timothy L. Bailey; Charles P. Elkan; Michael E. Baker
• Keywords: Motif (music)

Motivation:Modeling families of related biological sequences using Hidden Markov models (HMMs), although increasingly widespread, faces at least one major problem: because the complexity these mathematical models, they require a relatively large training set in order to accurately recognize given family. For which there are few known sequences, standard linear HMM contains too many parameters be trained adequately