The HMMTOP transmembrane topology prediction server

0301 basic medicine 0303 health sciences 03 medical and health sciences Models, Statistical Database Management Systems Humans Membrane Proteins Computer Simulation Databases, Protein Algorithms Markov Chains Protein Structure, Secondary Software
DOI: 10.1093/bioinformatics/17.9.849 Publication Date: 2002-09-30T14:33:00Z
ABSTRACT
Abstract Summary: The HMMTOP transmembrane topology prediction server predicts both the localization of helical transmembrane segments and the topology of transmembrane proteins. Recently, several improvements have been introduced to the original method. Now, the user is allowed to submit additional information about segment localization to enhance the prediction power. This option improves the prediction accuracy as well as helps the interpretation of experimental results, i.e. in epitope insertion experiments. Availability: HMMTOP 2.0 is freely available to non-commercial users at http://www.enzim.hu/hmmtop. Source code is also available upon request to academic users. Contact: tusi@enzim.hu * To whom correspondence should be addressed.
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