OverProt: secondary structure consensus for protein families

• DOI: 10.1093/bioinformatics/btac384
• Publication Date: 2022-06-08T12:10:04Z
• Authors: Adam Midlik; Ivana Hutařová Va...; Jan Hutař; Aliaksei Chareshneu; Karel Berka; Radka Svobodová
• Keywords: Consensus; Computers; 0206 medical engineering; Proteins; 02 engineering and technology; Software; Protein Structure, Secondary

AbstractSummaryEvery protein family has a set of characteristic secondary structures. However, due to individual variations, a single structure is not enough to represent the whole family. OverProt can create a secondary structure consensus, showing the general fold of the family as well as its variation. Our server provides precomputed results for all CATH superfamilies and user-defined computations, visualized by an interactive viewer, which shows the secondary structure element type, length, frequency of occurrence, spatial variability and β-connectivity.Availability and implementationOverProt Server is freely available at https://overprot.ncbr.muni.cz.Supplementary informationSupplementary data are available at Bioinformatics online.