MIX-TPI: a flexible prediction framework for TCR–pMHC interactions based on multimodal representations

• DOI: 10.1093/bioinformatics/btad475
• Publication Date: 2023-08-01T16:24:13Z
• Authors: Minghao Yang; Zhi-An Huang; Wei Zhou; Junkai Ji; Jun Zhang; Shan He; Zexuan Zhu
• Keywords: Major Histocompatibility Complex; 0301 basic medicine; Original Paper; 03 medical and health sciences; Receptors, Antigen, T-Cell; Amino Acid Sequence; Peptides; Software; Protein Binding

The interactions between T-cell receptors (TCR) and peptide-major histocompatibility complex (pMHC) are essential for the adaptive immune system. However, identifying these can be challenging due to limited availability of experimental data, sequence data heterogeneity, high validation costs.