Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria–Delbrück fluctuation analysis

• DOI: 10.1093/bioinformatics/btp253
• Publication Date: 2009-04-16T01:28:58Z
• Authors: Brandon M. Hall; Chang-Xing Ma; Ping Liang; Keshav K. Singh
• Keywords: Internet; Likelihood Functions; 0303 health sciences; 03 medical and health sciences; Databases, Genetic; Mutation; Computational Biology; Software

Abstract Summary:The program Fluctuation AnaLysis CalculatOR (FALCOR) is a web tool designed for use with Luria–Delbrück fluctuation analysis to calculate the frequency and rate from various mutation assays in bacteria and yeast. Three calculation methods are available through this program: (i) Ma-Sandri-Sarkar Maximum Likelihood Estimator (MSS-MLE) method, (ii) Lea-Coulson method of the median (LC) and (iii) frequency. Availability: The FALCOR rate calculator is currently accessible at http://www.mitochondria.org/protocols/FALCOR.html. This program is written as a Java™ Applet, requiring a web browser enabled with Sun MicroSystems' Java Virtual Machine. Contact: [e-mail]