InterMap3D: predicting and visualizing co-evolving protein residues

• DOI: 10.1093/bioinformatics/btp335
• Publication Date: 2009-06-16T00:26:03Z
• Authors: Rodrigo Gouveia-O...; Francisco S. Roque; Rasmus Wernersson; Thomas Sicheritz-...; Peter W. Sackett; Anne Mølgaard; Anders G. Pedersen
• Keywords: Protein Data Bank; Protein superfamily; Multiple sequence alignment; Structural alignment

Abstract Summary: InterMap3D predicts co-evolving protein residues and plots them on the 3D structure. Starting with a single sequence, automatically finds set of homologous sequences, generates an alignment fetches most similar structure from Protein Data Bank (PDB). It can also accept user-generated alignment. Based alignment, are then predicted using three different methods: Row Column Weighing Mutual Information, Information/Entropy Dependency. Finally, high-quality images highlighted. Availability: http://www.cbs.dtu.dk/services/InterMap3D/ Contact: [e-mail]