ITM Probe: analyzing information flow in protein networks

• DOI: 10.1093/bioinformatics/btp398
• Publication Date: 2009-06-28T00:13:44Z
• Authors: Aleksandar Stojmi...; Yi-Kuo Yu
• Keywords: 0303 health sciences; Molecular Networks (q-bio.MN); Computational Biology; Proteins; Quantitative Biology - Quantitative Methods; Applications Note; 03 medical and health sciences; FOS: Biological sciences; Protein Interaction Mapping; Quantitative Biology - Molecular Networks; Databases, Protein; Software; Quantitative Methods (q-bio.QM)

Abstract Summary: Founded upon diffusion with damping, ITM Probe is an application for modeling information flow in protein interaction networks without prior restriction to the sub-network of interest. Given a context consisting of desired origins and destinations of information, ITM Probe returns the set of most relevant proteins with weights and a graphical representation of the corresponding sub-network. With a click, the user may send the resulting protein list for enrichment analysis to facilitate hypothesis formation or confirmation. Availability: ITM Probe web service and documentation can be found at www.ncbi.nlm.nih.gov/CBBresearch/qmbp/mn/itm_probe Contact: [e-mail]