DCDB: Drug combination database

• DOI: 10.1093/bioinformatics/btp697
• Publication Date: 2009-12-24T01:52:12Z
• Authors: Yanbin Liu; Bin Hu; Chengxin Fu; Xin Chen
• Keywords: 0301 basic medicine; Internet; PubMed; Databases, Factual; Drug Industry; United States Food and Drug Administration; 0206 medical engineering; Computational Biology; 02 engineering and technology; United States; 3. Good health; Drug Combinations; 03 medical and health sciences; Drug Design

Abstract Summary: Rapid advances in pharmaceutical sciences have brought ever-increasing interests in combined therapies for better clinical efficacy and safety, especially in cases of complicated and refractory diseases. Innovative experimental technologies and theoretical frameworks are being actively developed for multicomponent drug research. In this work, we present the Drug Combination Database, with aims to facilitate analyses of known drug combinations, to summarize patterns of beneficial drug interactions, and to provide a basis for theoretical modeling and simulation of such drug interactions. Its current version (1.0) collected 499 approved or investigational drug combinations, including 40 unsuccessful drug combinations, involving 485 individual drugs, from >6000 references. Availability: http://www.cls.zju.edu.cn/dcdb/. Contact: [e-mail] Supplementary information: Supplementary data are available at the database website and Bioinformatics online.