MetalionRNA: computational predictor of metal-binding sites in RNA structures

• DOI: 10.1093/bioinformatics/btr636
• Publication Date: 2011-11-23T02:11:40Z
• Authors: Anna Philips; Kaja Milanowska; Grzegorz Lach; Michal Boniecki; Kristian Rother; Janusz M. Bujnicki
• Keywords: Nucleic acid structure; Folding (DSP implementation)

Abstract Motivation: Metal ions are essential for the folding of RNA molecules into stable tertiary structures and often involved in catalytic activity ribozymes. However, positions metal 3D difficult to determine experimentally. This motivated us develop a computational predictor ion sites structures. Results: We developed statistical potential predicting (magnesium, sodium potassium), based on analysis binding experimentally solved The MetalionRNA program is available as web server that predicts submitted by user. Availability: accessible at http://metalionrna.genesilico.pl/. Contact: [e-mail] Supplementary information: data Bioinformatics online.