CLARE: Cracking the LAnguage of Regulatory Elements

• DOI: 10.1093/bioinformatics/btr704
• Publication Date: 2011-12-24T02:37:52Z
• Authors: Leila Taher; Leelavati Narlikar; Ivan Ovcharenko
• Keywords: Sequence (biology)

Abstract Summary: CLARE is a computational method designed to reveal sequence encryption of tissue-specific regulatory elements. Starting with set elements known be active in particular tissue/process, it learns the code input and builds predictive model from features specific those The resulting can then applied user-supplied genomic regions identify novel candidate CLARE's also provides detailed analysis transcription factors that most likely bind elements, making an invaluable tool for understanding mechanisms gene regulation. Availability: freely accessible at http://clare.dcode.org/. Contact: [e-mail]; [e-mail] Supplementary information: data are available Bioinformatics online.