CLARE: Cracking the LAnguage of Regulatory Elements

Sequence (biology)
DOI: 10.1093/bioinformatics/btr704 Publication Date: 2011-12-24T02:37:52Z
ABSTRACT
Abstract Summary: CLARE is a computational method designed to reveal sequence encryption of tissue-specific regulatory elements. Starting with set elements known be active in particular tissue/process, it learns the code input and builds predictive model from features specific those The resulting can then applied user-supplied genomic regions identify novel candidate CLARE's also provides detailed analysis transcription factors that most likely bind elements, making an invaluable tool for understanding mechanisms gene regulation. Availability: freely accessible at http://clare.dcode.org/. Contact: taherl@ncbi.nlm.nih.gov; ovcharen@nih.gov Supplementary information: data are available Bioinformatics online.
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