SynaptomeDB: an ontology-based knowledgebase for synaptic genes

• DOI: 10.1093/bioinformatics/bts040
• Publication Date: 2012-01-28T05:35:03Z
• Authors: Mehdi Pirooznia; Tao Wang; Dimitrios Avramop...; David Valle; Gareth Thomas; Richard L. Huganir; Fernando S. Goes; James B. Potash; Peter P. Zandi
• Keywords: ENCODE

Abstract Motivation: The synapse is integral to the function of brain and may be an important source dysfunction underlying many neuropsychiatric disorders. Consequently, it excellent candidate for large-scale genomic proteomic study. However, while tools databases available annotation high-throughput DNA protein are generally robust, a comprehensive resource dedicated integration information about lacking. Results: We present integrated database, called SynaptomeDB, retrieve annotate genes comprising synaptome. These encode components including neurotransmitters their receptors, adhesion/cytoskeletal proteins, scaffold membrane transporters. SynaptomeDB integrates various complex data sources synaptic proteins. Availability: http://psychiatry.igm.jhmi.edu/SynaptomeDB/ Contact: [e-mail] Supplementary information: at Bioinformatics online.