Allosite: a method for predicting allosteric sites

• DOI: 10.1093/bioinformatics/btt399
• Publication Date: 2013-07-11T00:34:28Z
• Authors: Wenkang Huang; Shaoyong Lu; Zhimin Huang; Xinyi Liu; Linkai Mou; Yu Luo; Yanlong Zhao; Yaqin Liu; Zhongjie Chen; Tingjun Hou; Jian Zhang
• Keywords: 0301 basic medicine; 03 medical and health sciences; Drug Discovery; Proteins; Ligands; Algorithms; Allosteric Site; Software; 3. Good health

Abstract Motivation: The use of allosteric modulators as preferred therapeutic agents against classic orthosteric ligands has colossal advantages, including higher specificity, fewer side effects and lower toxicity. Therefore, the computational prediction sites in proteins is receiving increased attention field drug discovery. Allosite a newly developed automatic tool for interest now available through web server. Availability: server tutorials are freely at http://mdl.shsmu.edu.cn/AST Contact: [e-mail] Supplementary information: data Bioinformatics online.