DSigDB: drug signatures database for gene set analysis

• DOI: 10.1093/bioinformatics/btv313
• Publication Date: 2015-05-20T02:51:09Z
• Authors: Minjae Yoo; Jimin Shin; Jihye Kim; Karen A. Ryall; Kyubum Lee; Sunwon Lee; Minji Jeon; Jaewoo Kang; Aik Choon Tan
• Keywords: Drug repositioning; Repurposing

Abstract Summary: We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for enrichment analysis (GSEA). DSigDB currently holds 22 527 sets, consists 17 389 unique compounds covering 19 531 genes. also developed an online allows users to search, view download sets. sets provide seamless integration GSEA software linking expressions with drug repurposing translational research. Availability implementation: is freely available non-commercial use at http://tanlab.ucdenver.edu/DSigDB. Supplementary information: data are Bioinformatics online. Contact: [e-mail]