BetaSerpentine: a bioinformatics tool for reconstruction of amyloid structures

• DOI: 10.1093/bioinformatics/btx629
• Publication Date: 2017-10-03T11:10:21Z
• Authors: Stanislav A Bondarev; Olga V Bondareva; Galina A Zhouravleva; Andrey V Kajava
• Keywords: Structural bioinformatics; Code (set theory)

Numerous experimental studies have suggested that polypeptide chains of large amyloidogenic regions zig-zag in β-serpentine arrangements. These β-serpentines are stacked axially and form the superpleated β-structure. Despite this progress understanding amyloid folds, determination their 3D structure at atomic level is still a problem due to polymorphism these fibrils incompleteness structural data. Today, way get insight into amyloids combination with bioinformatics.We developed computer program BetaSerpentine reconstructs arrangements from individual β-arches predicted by ArchCandy ranks them order preference. It was shown data can be used gain detailed amyloids. opens avenues structure-based interpretation design experiments.BetaSerpentine webserver accessed through website: http://bioinfo.montp.cnrs.fr/b-serpentine. Source code available git.hub repository (github.com/stanislavspbgu/BetaSerpentine)[e-mail] or [e-mail] Bioinformatics online.