Database of evidence for precision oncology portal

• DOI: 10.1093/bioinformatics/bty531
• Publication Date: 2018-06-27T19:37:29Z
• Authors: Sam Q Sun; R Jay Mashl; Sohini Sengupta; Adam D Scott; Weihua Wang; Prag Batra; Liang-Bo Wang; Matthew A Wyczalk...; Li Ding
• Keywords: Search Engine; 0301 basic medicine; Internet; 03 medical and health sciences; Databases, Factual; Neoplasms; Humans; Genomics; Precision Medicine; Medical Oncology; 3. Good health

Abstract

Summary A database of curated genomic variants with clinically supported drug therapies and other oncological annotations is described. The accompanying web portal provides a search engine with two modes: one that allows users to query gene, cancer type, variant type or position for druggable mutations, and another to search for and to visualize, on three-dimensional protein structures, putative druggable sites that cluster with known druggable mutations.

Availability and implementation http://dinglab.wustl.edu/depo