The substantia nigra of the human brain

• DOI: 10.1093/brain/122.8.1437
• Publication Date: 2002-07-26T22:47:12Z
• Authors: P. Damier; E. C. Hirsch; Y. Agid; A. M. Graybiel
• Keywords: Pars compacta; Pars reticulata

To achieve accuracy in studying the patterns of loss midbrain dopamine-containing neurons Parkinson's disease, we used compartmental calbindin D28K immunostaining to subdivide substantia nigra with landmarks independent degenerative process. Within pars compacta, identified calbindin-rich regions (`matrix') and five calbindin-poor pockets (`nigrosomes') defined by analysis three-dimensional networks formed zones. These zones were recognizable all brains, despite severe neurons. The degree compacta was related duration cell followed a strict order. neuronal significantly higher nigrosomes than matrix. Depletion maximum (98%) main pocket (nigrosome 1), located caudal mediolateral part compacta. Progressively less detectable more medial rostral nigrosomes, following stereotyped order nigrosome 1 > 2 4 3 5. A parallel, but lesser, caudorostral gradient observed for included This pattern consistent from one parkinsonian another. spatiotemporal progression disease can thus be drawn each patient: depletion begins 1) then spreads other matrix along rostral, dorsal axes progression.