Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

• DOI: 10.1093/brain/awaa096
• Publication Date: 2020-03-17T20:10:55Z
• Authors: Marie-Laure Arotc...; Sandra Dovero; Alice Prigent; Mathieu Bourdenx; Sandrine Camus; Gregory Porras; Marie-Laure Thiolat; Maddalena Tasselli; Philippe Aubert; Niels Kruse; Brit Mollenhauer; Ines Trigo Damas; Cristina Estrada; Nuria Garcia-Carr...; Nishant N Vaikath; Omar M A El-Agnaf; Maria Trinidad He...; Miquel Vila; Jose A Obeso; Pascal Derkinderen; Benjamin Dehay; Erwan Bezard
• Keywords: Dorsal motor nucleus; Enteric Nervous System

Abstract In Parkinson’s disease, synucleinopathy is hypothesized to spread from the enteric nervous system, via vagus nerve, CNS. Here, we compare, in baboon monkeys, pathological consequences of either intrastriatal or injection α-synuclein-containing Lewy body extracts patients with disease. This study shows that patient-derived α-synuclein aggregates are able induce nigrostriatal lesions and system pathology after striatal a non-human primate model. finding suggests progression might be caudo-rostral rostro-caudal, varying between disease subtypes. addition, report were not found vagal nerve our experimental setting. does support hypothesis transmission through dorsal motor nucleus vagus. Instead, results suggest possible systemic mechanism which general circulation would act as route for long-distance bidirectional endogenous central systems. Taken together, provides invaluable data exploring role gut-brain axis initiation propagation should open door development testing new therapeutic approaches aimed at interfering sporadic