Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

Dorsal motor nucleus Enteric Nervous System
DOI: 10.1093/brain/awaa096 Publication Date: 2020-03-17T20:10:55Z
ABSTRACT
Abstract In Parkinson’s disease, synucleinopathy is hypothesized to spread from the enteric nervous system, via vagus nerve, CNS. Here, we compare, in baboon monkeys, pathological consequences of either intrastriatal or injection α-synuclein-containing Lewy body extracts patients with disease. This study shows that patient-derived α-synuclein aggregates are able induce nigrostriatal lesions and system pathology after striatal a non-human primate model. finding suggests progression might be caudo-rostral rostro-caudal, varying between disease subtypes. addition, report were not found vagal nerve our experimental setting. does support hypothesis transmission through dorsal motor nucleus vagus. Instead, results suggest possible systemic mechanism which general circulation would act as route for long-distance bidirectional endogenous central systems. Taken together, provides invaluable data exploring role gut-brain axis initiation propagation should open door development testing new therapeutic approaches aimed at interfering sporadic
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