Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury

• DOI: 10.1093/brain/awad056
• Publication Date: 2023-02-22T16:45:54Z
• Authors: Rebecca E Woodrow; Stefan Winzeck; Andrea I Luppi; Isaac R Kelleher-...; Lennart R B Spindler; J T Lindsay Wilson; Virginia F J Newc...; Jonathan P Coles; ; Krisztina Amrein; Nada Andelic; Lasse Andreassen; Audny Anke; Philippe Azouvi; Bo-Michael Bellander; Habib Benali; Andras Buki; Alessio Caccioppola; Emiliana Calappi; Marco Carbonara; Giuseppe Citerio; Hans Clusmann; Mark Coburn; Jonathan Coles; Marta Correia; Endre Czeiter; Véronique De Keyser; Vincent Degos; Bart Depreitere; Live Eikenes; Erzsébet Ezer; Kelly Foks; Shirin Frisvold; Alexandre Ghuysen; Damien Galanaud; Ben Glocker; Asta Haberg; Iain Haitsma; Eirik Helseth; Peter J Hutchinson; Evgenios Kornarop...; Noémi Kovács; Ana Kowark; Steven Laureys; Didier Ledoux; Hester Lingsma; Andrew I R Maas; Geoffrey Manley; David K Menon; Tomas Menovsky; Benoit Misset; Visakh Muraleedharan; Ingeborg Nakken; Virginia Newcombe; Wibeke Nordhøy; József Nyirádi; Fabrizio Ortolano; Paul M Parizel; Vincent Perlbarg; Paolo Persona; Wilco Peul; Jussi P Posti; Louis Puybasset; Sophie Richter; Cecilie Roe; Olav Roise; Rolf Rossaint; Sandra Rossi; Daniel Rueckert; Toril Skandsen; Abayomi Sorinola; Emmanuel Stamatakis; Ewout W Steyerberg; Nino Stocchetti; Riikka Takala; Viktória Tamás; Olli Tenovuo; Zoltán Vámos; Gregory Van der S...; Wim Van Hecke; Thijs Vande Vyvere; Jan Verheyden; Anne Vik; Victor Volovici; Lars T Westlye; Guy Williams; Stefan Winzeck; Peter Ylén; Tommaso Zoerle; David K Menon; Emmanuel A Stamat...
• Keywords: Chronic traumatic encephalopathy

Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical associations our findings using PET data. Of the cohort, 47% showed incomplete recovery 6 months post-injury. Despite absence changes, we found hyperconnectivity mTBI, specific vulnerabilities individual nuclei. Acute fMRI differentiated those chronic symptoms, time- outcome-dependent relationships sub-cohort followed longitudinally. Moreover, emotional cognitive associated known serotonergic noradrenergic targets, respectively. Our suggest that can have basis pathophysiology. This aid identification at risk following provide development new therapies facilitate precision medicine application these therapies.