DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

• DOI: 10.1093/brain/awt237
• Publication Date: 2013-09-13T21:05:17Z
• Authors: Jose V. Sanchez-Mut; Ester Aso; Nicolas Panayotis; Ira Lott; Mara Dierssen; Alberto Rabano; Rocio G. Urdinguio; Agustin F. Fernandez; Aurora Astudillo; Jose I. Martin-Su...; Balazs Balint; Mario F. Fraga; Antonio Gomez; Cecile Gurnot; Jean-Christophe Roux; Jesus Avila; Takao K. Hensch; Isidre Ferrer; Manel Esteller
• Keywords: CpG site

The central nervous system has a pattern of gene expression that is closely regulated with respect to functional and anatomical regions. DNA methylation major regulator transcriptional activity, aberrations in the distribution this epigenetic mark may be involved many neurological disorders, such as Alzheimer's disease. Herein, we have analysed 12 distinct mouse brain regions according their CpG 5'-end patterns observed unique landscapes. methylomes obtained from cerebral cortex were used identify aberrant changes occurred two models We able translate these findings patients disease, identifying methylation-associated silencing three targets genes: thromboxane A2 receptor (TBXA2R), sorbin SH3 domain containing 3 (SORBS3) spectrin beta 4 (SPTBN4). These hypermethylation indicate cyclic AMP response element-binding protein (CREB) activation pathway axon initial segment could contribute