Resilience of developing brain networks to interictal epileptiform discharges is associated with cognitive outcome

• DOI: 10.1093/brain/awu214
• Publication Date: 2014-08-08T01:19:00Z
• Authors: George M. Ibrahim; Daniel Cassel; Benjamin R. Morgan; Mary Lou Smith; Hiroshi Otsubo; Ayako Ochi; Margot Taylor; James T. Rutka; O. Carter Snead; Sam Doesburg
• Keywords: Magnetoencephalography; Neurocognitive

The effects of interictal epileptiform discharges on neurocognitive development in children with medically-intractable epilepsy are poorly understood. Such may have a deleterious effect the brain's intrinsic connectivity networks, which reflect organization functional networks at rest, and turn development. Using combined magnetic resonance imaging-magnetoencephalography approach, we examine outcome. Functional imaging was used to determine location regions comprising various 26 (7-17 years), magnetoencephalography data were reconstructed from these locations. Inter-regional phase synchronization then calculated across graph theoretical analysis applied measure event-related changes network topology peri-discharge period. magnitude change (network resilience/vulnerability) associated outcomes using dual regression. Three main findings reported: (i) large-scale precede follow discharges; (ii) resilience topologies is stronger resting-state connectivity; (iii) vulnerability worse outcomes. By combining spatial resolution temporal magnetoencephalography, describe neurophysiological synchrony establish impact disruption cognitive outcome epilepsy. association between discharges, suggests that it clinical importance suppress foster more typical brain focal