Energy expenditure in frontotemporal dementia: a behavioural and imaging study

• DOI: 10.1093/brain/aww263
• Publication Date: 2016-10-03T11:05:25Z
• Authors: Rebekah M. Ahmed; Ramon Landin-Romero; Tinh-Hai Collet; Agatha A. van der...; Emma Devenney; Elana Henning; Matthew C. Kiernan; Olivier Piguet; I. Sadaf Farooqi; John R. Hodges
• Keywords: Male; Physiology; Heart rate; frontotemporal dementia; Alzheimer Disease; Heart Rate; info:eu-repo/classification/ddc/616; heart rate; Humans; Autonomic function; Aged; Cerebral Cortex; 2. Zero hunger; Feeding Behavior; Middle Aged; Magnetic Resonance Imaging; 3. Good health; Metabolism; Autonomic Nervous System Diseases; Frontotemporal Dementia; physiology; Female; autonomic function; Atrophy; Energy Metabolism; metabolism; Frontotemporal dementia

SEE FINGER DOI101093/AWW312 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Abnormal eating behaviour and metabolic parameters including insulin resistance, dyslipidaemia body mass index are increasingly recognized as important components of neurodegenerative disease may contribute to survival. It has previously been established that behavioural variant frontotemporal dementia is associated with abnormal characterized by increased sweet preference. In this study, it was hypothesized might also be altered energy expenditure. cohort 19 patients dementia, 13 Alzheimer's 16 (age- sex-matched) healthy control subjects were studied using Actiheart devices (CamNtech) assess resting stressed heart rate. fitted for 7 days measure sleeping rate, activity levels, resting, active total Using high resolution structural magnetic resonance imaging the neural correlates rate investigated cortical thickness region interest analyses. (P = 0.001), 0.037) 0.038) compared subjects, 0.020) Alzheimer patients. Behavioural decreased levels controls 0.002) expenditure 0.045) 0.035). Increased correlated (Cambridge Inventory) cognitive measures (Addenbrooke's Cognitive Examination). in atrophy involving mesial temporal cortex, insula, amygdala, regions suggested involved exclusively social emotion processing dementia. These overlap network suggesting a complex interaction between behaviour, autonomic function homeostasis. As such present study suggests changes prevalent An understanding these have potential relevance progression prognosis.