Williams syndrome hemideletion and LIMK1 variation both affect dorsal stream functional connectivity

• DOI: 10.1093/brain/awz323
• Publication Date: 2019-10-01T15:26:43Z
• Authors: Michael D Gregory; Carolyn B Mervis; Maxwell L Elliott; J Shane Kippenhan; Tiffany Nash; Jasmin B. Czarapata; Ranjani Prabhakaran; Katherine Roe; Daniel P Eisenberg; Philip D Kohn; Karen F Berman
• Keywords: Adult; Male; Williams Syndrome; Adolescent; Lim Kinases; Middle Aged; Magnetic Resonance Imaging; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Haplotypes; Child, Preschool; Parietal Lobe; Humans; Female; Nerve Net; Child

In Williams syndrome, a condition marked by hypersociability and visuospatial impairment, Gregory et al. show that intraparietal sulcus functional connectivity is increased with social processing regions and decreased with visual processing regions. Variation in LIMK1, which is hemideleted in Williams syndrome, is also associated with functional connectivity patterns in healthy controls.