Alpha-synuclein seeds in olfactory mucosa and cerebrospinal fluid of patients with dementia with Lewy bodies

• DOI: 10.1093/braincomms/fcab045
• Publication Date: 2021-03-20T04:18:03Z
• Authors: Daniela Perra; Matilde Bongianni; Giovanni Novi; Francesco Janes; Valentina Bessi; Stefano Capaldi; Luca Sacchetto; Matteo Tagliapietra; Guido Schenone; Silvia Morbelli; Michele Fiorini; Tatiana Cattaruzza; Giulia Mazzon; Christina D Orrù; Mauro Catalan; Paola Polverino; Andrea Bernardini; Gaia Pellitteri; Mariarosa Valente; Claudio Bertolotti; Benedetta Nacmias; Giandomenico Magg...; Tiziana Cavallaro; Paolo Manganotti; Gianluigi Gigli; Salvatore Monaco; Flavio Nobili; Gianluigi Zanusso
• Keywords: Olfactory mucosa; Lewy body

In patients with suspected dementia Lewy bodies, the detection of disease-associated α-synuclein in easily accessible tissues amenable to be collected using minimally invasive procedures remains a major diagnostic challenge. This approach has potential take advantage modern molecular assays for diagnosis α-synucleinopathy and, turn, optimize recruitment and selection clinical trials, drugs directed at counteracting aggregation. this study, we explored accuracy real-time quaking-induced conversion assay by testing olfactory mucosa CSF probable (