MRI-derived g-ratio and lesion severity in newly diagnosed multiple sclerosis

• DOI: 10.1093/braincomms/fcab249
• Publication Date: 2021-10-31T12:07:00Z
• Authors: Elizabeth N York; Sarah-Jane Martin; Rozanna Meijboom; Michael J Thrippl...; Mark E Bastin; Edwin Carter; James Overell; Peter Connick; Siddharthan Chandran; Adam D Waldman; David P J Hunt; ; Amit Akula; Javier Carod Artal; Sergio Baranzini; Fiona Barret; Mark Bastin; Christine Batchelor; Emily Beswick; Fraser Brown; Siddharthan Chandran; Jessie Chang; Yingdi Chen; Shuna Colville; Peter Connick; Denise Cranley; Rachel Dakin; Baljean Dhillon; Elizabeth Elliot; James Finlayson; Peter Foley; Stella Glasmacher; Angus Grossart; Haane Haagenrud; Katarzyna Hafezi; Emily Harrison; Adil Harroud; Sara Hathorn; Tracey Hopkins; David Hunt; Aidan Hutchinson; Kiran Jayprakash; Matt Justin; Agniete Kampaite; Patrick Kearns; Gwen Kennedy; Michaela Kleynhans; Julian Ng Kee Kwong; Juan Larraz; Kathryn Love; Dawn Lyle; James MacDonald; Niall MacDougall; Lesley Macfarlane; Beverly Maclennan; Alan Maclean; Margaret Ann MacLeod; Nicola Macleod; Don Mahad; Sarah Jane Martin; Lynn McMahon; Ian Megson; Rozanna Meijboom; Daisy Mollison; Mary Monaghan; Lee Murphy; Katy Murray; Judith Newton; Jonathan O’Riordan; David Perry; Suzanne Quigley; Adam Scotson; Amy Stenson; Michael Thrippleton; Maria Valdez Hern...; Adam Waldman; Christine Weaver; Stewart Webb; Belinda Weller; Anna Williams; Stewart Wiseman; Charis Wong; Michael Wong; Elizabeth York
• Keywords: Neurofilament

Abstract Myelin loss is associated with axonal damage in established multiple sclerosis. This relationship challenging to study vivo early disease. Here, we ask whether myelin at diagnosis by combining non-invasive neuroimaging and blood biomarkers. We performed quantitative microstructural MRI single-molecule ELISA plasma neurofilament measurement 73 patients newly diagnosed, immunotherapy naïve relapsing–remitting integrity was evaluated using aggregate g-ratios, derived from magnetization transfer saturation neurite orientation dispersion density imaging diffusion data. found significantly higher g-ratios within cerebral white matter lesions (suggesting loss) compared normal-appearing (0.61 versus 0.57, difference 0.036, 95% CI: 0.029–0.043, P < 0.001). Lesion volume (Spearman’s rho rs= 0.38, 0.001) g-ratio (rs= 0.24, 0.05) correlated independently neurofilament. In substantial lesion load (n = 38), those (defined as greater than median) were more likely have abnormally elevated normal less [11/23 (48%) 2/15 (13%), 0.05]. These data suggest that, even sclerosis diagnosis, reduced damage. MRI-derived may provide useful additional information regarding severity help identify individuals a high degree of disease onset.