Neuroanatomical correlations of visuospatial processing in primary progressive aphasia

• DOI: 10.1093/braincomms/fcac060
• Publication Date: 2022-03-11T04:12:44Z
• Authors: Boon Lead Tee; Christa Watson Pe...; Sladjana Lukic; Lynn P. Bajorek; Isabel Elaine Allen; Zachary A. Miller; Kaitlin B. Casaletto; Bruce L. Miller; Maria Luisa Gorno...
• Keywords: Primary progressive aphasia; Aphasiology

Clinical phenotyping of primary progressive aphasia has largely focused on speech and language presentations, leaving other cognitive domains under-examined. This study investigated the diagnostic utility visuospatial profiles examined their neural basis among three main variants. We studied neuropsychological performances 118 participants 30 cognitively normal controls, across 11 measures cognition, correlates via voxel-based morphometry analysis using composite scores derived from principal component analysis. The identified factors: visuospatial-executive, visuospatial-memory visuomotor components. Logopenic variant performed significantly worst all components; nonfluent/agrammatic showed deficits in visuospatial-executive components compared with controls; semantic scored lower than control component. Grey matter volumes over right parieto-occipital cortices correlated performance; volumetric changes anterior parahippocampal gyrus amygdala were associated function, grey volume at precentral gyrus. Discriminant function measures: Visual Object Space Perception Benson figure copy recall test, which classified 79.7% (94/118) into specific variant. shows that each also carries a distinctive profile corresponds turn can be represented by performance visuomotor, executive functions.