Parasagittal dural space hypertrophy and amyloid-β deposition in Alzheimer’s disease

• DOI: 10.1093/braincomms/fcad128
• Publication Date: 2023-04-18T08:36:07Z
• Authors: Alexander K Song; Kilian Hett; Jarrod J Eisma; Colin D McKnight; Jason Elenberger; Adam J Stark; Hakmook Kang; Yan Yan; Ciaran M Considine; Manus J Donahue; Daniel O Claassen
• Keywords: Glymphatic System; Amyloid (mycology); Human brain

Abstract One of the pathological hallmarks Alzheimer’s and related diseases is increased accumulation protein amyloid-β in brain parenchyma. As such, recent studies have focused on characterizing clearance pathways involving perivascular flow neurofluids, but human these are limited owing to methods for evaluating neurofluid circulation non-invasively vivo. Here, we utilize non-invasive MRI explore surrogate measures CSF production, bulk egress context independent PET older adults. Participants (N = 23) were scanned at 3.0 T with 3D T2-weighted turbo spin echo, 2D perfusion-weighted pseudo-continuous arterial labelling phase-contrast angiography quantify parasagittal dural space volume, choroid plexus perfusion net through aqueduct Sylvius, respectively. All participants also underwent dynamic imaging tracer 11C-Pittsburgh Compound B global cerebral accumulation. Spearman’s correlation analyses revealed a significant relationship between volume (rho 0.529, P 0.010), specifically frontal 0.527, 0.010) parietal 0.616, 0.002) subsegments. No relationships observed nor flow. Findings suggest that hypertrophy, its possible role CSF-mediated clearance, may be closely These findings discussed our growing understanding physiological mechanisms aggregation via neurofluids.