Disinhibition in dementia related to reduced morphometric similarity of cognitive control network

• DOI: 10.1093/braincomms/fcae124
• Publication Date: 2024-04-16T18:55:21Z
• Authors: Lisanne M Jenkins; Ashley Heywood; Sonya Gupta; Maryam Kouchakidi...; Jaiashre Sridhar; Emily Rogalski; Sandra Weintraub; Karteek Popuri; Howard Rosen; Lei Wang; ; Howard Rosen; Bradford C Dickerson; Kimoko Domoto-Reilly; David Knopman; Bradley F Boeve; Adam L Boxer; John Kornak; Bruce L Miller; William W Seeley; Maria-Luisa Gorno...; Scott McGinnis; Maria Luisa Mandelli
• Keywords: Disinhibition

Abstract Disinhibition is one of the most distressing and difficult to treat neuropsychiatric symptoms dementia. It involves socially inappropriate behaviours, such as hypersexual comments, approaching strangers excessive jocularity. occurs in multiple dementia syndromes, including behavioural variant frontotemporal dementia, Alzheimer’s type. Morphometric similarity networks are a relatively new method for examining brain structure can be used calculate measures network integrity on large scale subnetworks salience cognitive control network. In cross-sectional study, we calculated morphometric determine whether disinhibition (n = 75) type 111) was associated with reduced these independent diagnosis. We found that presence disinhibition, measured by Neuropsychiatric Inventory Questionnaire, global efficiency both Future research should replicate this transdiagnostic finding other diagnoses imaging modalities, investigate potential intervention at level target disinhibition.