Tracts in the limbic system show microstructural alterations post COVID-19 recovery

• DOI: 10.1093/braincomms/fcae139
• Publication Date: 2024-05-07T08:53:19Z
• Authors: Sapna S Mishra; Caterina A Pedersini; Rohit Misra; Tapan K Gandhi; Bas Rokers; Bharat B Biswal
• Keywords: 2019-20 coronavirus outbreak

Delirium, memory loss, attention deficit and fatigue are frequently reported by COVID survivors, yet the neurological pathways underlying these symptoms not well understood. To study possible mechanisms for long-term sequelae after COVID-19 recovery, we investigated microstructural properties of white matter in Indian cohorts COVID-recovered patients healthy controls. For cross-sectional presented here, recruited 44 29 controls New Delhi, India. Using deterministic whole-brain tractography on acquired diffusion MRI scans, traced 20 tracts compared fractional anisotropy, axial, mean radial diffusivity between cohorts. Our results revealed statistically significant differences (