Fatigue in early multiple sclerosis: MRI metrics of neuroinflammation, relapse and neurodegeneration

• DOI: 10.1093/braincomms/fcae278
• Publication Date: 2024-08-14T18:12:38Z
• Authors: Rozanna Meijboom; Peter Foley; Niall J J MacDougall; Yair Mina; Elizabeth N York; Agniete Kampaite; Daisy Mollison; Patrick K A Kearns; Nicole White; Michael J Thrippl...; Katy Murray; Maria del C Valdé...; Daniel S Reich; Peter Connick; Steven Jacobson; Govind Nair; Siddharthan Chandran; Adam D Waldman
• Keywords: 0301 basic medicine; 0302 clinical medicine; Original Article

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the brain spinal cord. Fatigue common disabling symptom from MS onset, however mechanisms by which underlying processes cause fatigue remain unclear. Improved pathophysiological understanding offers potential for improved treatments MS-related fatigue. MRI provides insights into