Neurotoxic tau oligomers after single versus repetitive mild traumatic brain injury

• DOI: 10.1093/braincomms/fcz004
• Publication Date: 2019-08-07T06:54:40Z
• Authors: Alice Bittar; Nemil Bhatt; Tasneem F Hasan; Mauro Montalbano; Nicha Puangmalai; Salome McAllen; Anna Ellsworth; Mariana Carretero...; Giulio Taglialatela; Brandon Lucke-Wold; Aric Logsdon; Charles Rosen; Ryan C Turner; Rakez Kayed
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Article; 3. Good health

Mild traumatic brain injury accounts for the majority of head injuries and has been correlated with neurodegeneration dementia. While repetitive mild is highly to neurodegeneration, correlation a single still unclear. Because tau aggregates are main form induced pathology, toxic forms protein most likely play role in development post-mild neurodegeneration. Therefore, it becomes crucial characterize properties soluble versus injury. Herein, we isolated oligomers from wild-type mice exposed or characterized at functional, biochemical biophysical levels. We demonstrated that frequencies lead formation different oligomeric polymorphisms. These polymorphisms express long-term potentiation impairment potencies, toxicity potentials, morphologies strain indicating properties. To our knowledge, this first evidence derived distinct possibly correlate risk after