Intralobular distribution of preneoplastic foci in rat liver after a single dose of N-methyl-N-nitrosourea (MNU) following partial hepatectomy

• DOI: 10.1093/carcin/10.5.871
• Publication Date: 2012-11-19T21:59:34Z
• Authors: S. Maguire; H.M. Rabes
• Keywords: Nitrosourea

ATPase-deficient foci in rat liver, considered to be clonal origin and possible precursors of hepatocellular carcinomas, were induced by injecting male Wistar AF/Han (200-220 g) rats with N-methyl-N-nitrosourea (MNU) (25 mg/kg) 16 or 22 h after partial hepatectomy feeding for 80 days a diet containing phenobarbital. The animals killed 90 the intralobular distribution preneoplastic was analysed quantitatively. locations 48 16-h group 22-h determined from serial sections blocks liver five animals. mean distance portal vein (385 microns) 30% less than randomly selected points (546 microns), while (450 16% random (535 microns). diameter (235 17% greater (196 We suggest that cells early S phase which are periportally situated occupy an intermediary position at represent sensitive target population initiation.