Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis

• DOI: 10.1093/cercor/bhx301
• Publication Date: 2017-10-19T19:09:27Z
• Authors: Bahman Nasseroles...; Stefan Dukic; Michael Broderick; Kieran Mohr; Christina Schuster; Brighid Gavin; Russell McLaughlin; Mark Heverin; Alice Vajda; Parameswaran M Iyer; Niall Pender; Peter Bede; Edmund C Lalor; Orla Hardiman
• Keywords: EEG-fMRI

Amyotrophic lateral sclerosis (ALS) is a terminal progressive adult-onset neurodegeneration of the motor system. Although originally considered pure degeneration, there increasing evidence disease heterogeneity with varying degrees extra-motor involvement. How combined and nonmotor degeneration occurs in context broader disruption neural communication across brain networks has not been well characterized. Here, we have performed high-density crossectional longitudinal resting-state electroencephalography (EEG) recordings on 100 ALS patients 34 matched controls, identified characteristic patterns altered EEG connectivity that persisted analyses. These include strongly increased coherence between parietal–frontal scalp regions (in γ-band) bilateral over areas θ-band). Correlation structural MRI from same shows disease-specific corticospinal tracts parallels decrease activity areas, while associated less extensively involved exhibit significantly communication. Our findings demonstrate EEG-based mapping can provide novel insights into network decline ALS. data pave way for development validated cost-effective spectral biomarkers parallel changes imaging.