Macrophage migration inhibitory factor in the nucleus of solitary tract decreases blood pressure in SHRs

• DOI: 10.1093/cvr/cvs297
• Publication Date: 2012-09-21T02:05:45Z
• Authors: André Henrique Fr...; Graziela Torres B...; Hongwei Li; Eduardo Colombari; Débora Simões Alm...; Colin Sumners
• Keywords: Male; 0301 basic medicine; heart left ventricle pressure; enhanced green fluorescent protein; abdominal aorta; heart hypertrophy; Rats, Inbred WKY; parvovirus vector; Nucleus of the solitary tract; solitary tract nucleus; Heart Rate; Rats, Inbred SHR; heart rate; microinjection; Telemetry; rat; pressoreceptor reflex; viral gene therapy; Macrophage migration inhibitory factor; messenger RNA; telemetry; blood pressure regulation; Dependovirus; 3. Good health; Intramolecular Oxidoreductases; priority journal; antihypertensive activity; immunohistochemistry; Hypertension; Blood pressure; mean arterial pressure; in vivo gene transfer; Glutamate; nerve cell; hypertension; Microinjections; animal experiment; Genetic Vectors; 610; Cardiomegaly; animal tissue; reverse transcription polymerase chain reaction; 03 medical and health sciences; male; Solitary Nucleus; Animals; controlled study; Arterial Pressure; RNA, Messenger; Gene transfer; protein expression; Macrophage Migration-Inhibitory Factors; nonhuman; Animal; animal model; Genetic Therapy; Baroreflex; Rats; Disease Models, Animal; macrophage migration inhibition factor; Disease Models; Reactive oxygen species; viral gene delivery system

AimsThe macrophage migration inhibitory factor (MIF) is an intracellular inhibitor of the central nervous system actions angiotensin II on blood pressure. Considering that at nucleus solitary tract are important for maintenance hypertension in spontaneously hypertensive rats (SHRs), we tested if increased MIF expression SHR alters baseline high pressure these rats.