Best practices for the manual curation of intrinsically disordered proteins in DisProt

• DOI: 10.1093/database/baae009
• Publication Date: 2024-03-20T14:21:57Z
• Authors: Federica Quaglia; Anastasia Chasapi; Maria Victoria Nu...; Maria Cristina As...; Emanuela Leonardi; Damiano Piovesan; Silvio C E Tosatto
• Keywords: Intrinsically Disordered Proteins

Abstract The DisProt database is a resource containing manually curated data on experimentally validated intrinsically disordered proteins (IDPs) and regions (IDRs) from the literature. Developed in 2005, its primary goal was to collect structural functional information into that lack fixed three-dimensional structure. Today, has evolved major repository not only collects experimental but also contributes our understanding of IDPs/IDRs roles various biological processes, such as autophagy or life cycle mechanisms viruses their involvement diseases (such cancer neurodevelopmental disorders). offers detailed states IDPs/IDRs, including state transitions, interactions functions, all provided annotations. One central activities meticulous curation For this reason, ensure every expert volunteer curator possesses requisite knowledge for evaluation, collection integration, training courses materials are available. However, biocuration guidelines concur importance developing robust provide critical about consistency acquisition.This guideline aims both biocurators external users with best practices curating IDPs IDRs DisProt. It describes step literature process provides use cases IDP within Database URL: https://disprot.org/