CancerMHL: the database of integrating key DNA methylation, histone modifications and lncRNAs in cancer

• DOI: 10.1093/database/baae029
• Publication Date: 2024-04-13T16:30:27Z
• Authors: Pengyu Du; Yingli Chen; Qianzhong Li; Zhimin Gai; Hui Bai; Luqiang Zhang; Yuxian Liu; Yanni Cao; Yuanyuan Zhai; Wen Jin
• Keywords: 0303 health sciences; 03 medical and health sciences; Database Tool

Abstract The discovery of key epigenetic modifications in cancer is of great significance for the study of disease biomarkers. Through the mining of epigenetic modification data relevant to cancer, some researches on epigenetic modifications are accumulating. In order to make it easier to integrate the effects of key epigenetic modifications on the related cancers, we established CancerMHL (http://www.positionprediction.cn/), which provide key DNA methylation, histone modifications and lncRNAs as well as the effect of these key epigenetic modifications on gene expression in several cancers. To facilitate data retrieval, CancerMHL offers flexible query options and filters, allowing users to access specific key epigenetic modifications according to their own needs. In addition, based on the epigenetic modification data, three online prediction tools had been offered in CancerMHL for users. CancerMHL will be a useful resource platform for further exploring novel and potential biomarkers and therapeutic targets in cancer. Database URL: http://www.positionprediction.cn/