NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes

• DOI: 10.1093/database/bau015
• Publication Date: 2014-03-09T01:13:33Z
• Authors: Omer An; Vera Pendino; Matteo D’Antonio; Emanuele Ratti; Marco Gentilini; Francesca D. Cicc...
• Keywords: Ensembl

NCG 4.0 is the latest update of Network Cancer Genes, a web-based repository systems-level properties cancer genes. In its current version, database collects information on 537 known (i.e. experimentally supported) and 1463 candidate inferred using statistical methods) Candidate genes derive from manual revision 67 original publications describing mutational screening 3460 human exomes genomes in 23 different types. For all 2000 genes, duplicability, evolutionary origin, expression, functional annotation, interaction network with other proteins microRNAs are reported. addition to providing substantial cancer-related information, also introduces two new features. The first annotation possible false-positive drivers, defined as large-scale screenings whose association likely be spurious. second description 64 that causally involved progression (oncomiRs). Owing constitutes complete reliable resource coding non-coding deregulation drives onset and/or progression. can downloaded free application for Android smart phones. Database URL:http://bio.ieo.eu/ncg/