KOFFI and Anabel 2.0—a new binding kinetics database and its integration in an open-source binding analysis software

• DOI: 10.1093/database/baz101
• Publication Date: 2019-08-17T15:12:11Z
• Authors: Leo William Norval; Stefan Daniel Krämer; Mingjie Gao; Tobias Herz; Jianyu Li; Christin Rath; Johannes Wöhrle; Stefan Günther; Günter Roth
• Keywords: Receptor–ligand kinetics

The kinetics of featured interactions (KOFFI) database is a novel tool and resource for binding data from biomolecular interactions. While are abundant in literature, finding valuable information laborious task. We used text extraction methods to store rates (association, dissociation) as well corresponding meta-information (e.g. methods, devices) database. To date, over 270 articles were manually curated on 1705 was collected stored the Moreover, KOFFI application programming interface implemented Anabel (open-source software analysis interactions), enabling users directly compare their own analyses with related experiments described