RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome

• DOI: 10.1093/database/baz135
• Publication Date: 2019-11-06T07:13:14Z
• Authors: Chengyu Wang; Fan Yang; Tingting Chen; Qi Dong; Zhangxiang Zhao; Yaoyao Liu; Bo Chen; Haihai Liang; Huike Yang; Yunyan Gu
• Keywords: Hippo signaling pathway; Epigenomics

Abstract The Hippo signaling pathway is a highly conserved controlling organ size, cell proliferation, apoptosis and other biological functions. Recent studies have shown that also plays important roles in cancer initiation progression. However, database offering multi-omics analyses visualization of genes cancer, as well comprehensive regulatory relationships still lacking. To fill this gap, we constructed the Regulation Pathway Cancer Genome (RHPCG) database. Currently, RHPCG focuses on analyzing 21 core Hippo-protein-encoding over 10 000 patients across 33 TCGA (The Atlas) types at levels genomic, epigenomic transcriptomic landscape. Concurrently, provides its motif section 11 associated with containing 180 miRNAs, 6182 lncRNAs, 728 circRNAs 335 protein coding genes. Thus, powerful tool could help researchers understand gene alterations mechanisms cancer.