Elevated type-17 cytokines are present in axial spondyloarthritis stool

• DOI: 10.1093/discim/kyae005
• Publication Date: 2024-05-04T09:40:02Z
• Authors: India Brough; Kelsey Thompson; Ciara Latore; Frank Penkava; Chelsea Regan; Claire Pearson; Hui Shi; Anna Ridley; Davide Simone; Lilian Lam; Samuel Bullers; Caroline Moussa; Rachel Feeney; ; Mohammed H Al-Mos...; Fiona Powrie; Stephen Young; Curtis Huttenhower; Paul Bowness
• Keywords: Axial spondyloarthritis

Summary Axial spondyloarthritis (axSpA) is characterized by type-17 immune-driven joint inflammation, and intestinal inflammation present in around 70% of patients. In this study, we asked whether axSpA stool contained Th17-associated cytokines related to systemic Th17 activation. We measured cytokine calprotectin levels ELISA found that patients with have increased IL-17A, IL-23, GM-CSF, calprotectin. further identified circulating IL-17A+ IL-17F+ T-helper cell lymphocytes compared healthy donors. finally assessed metabolites unbiased nuclear magnetic resonance spectroscopy multiple amino acids were negatively correlated IL-23 concentrations. These data provide evidence immunity the lumen, suggest its association microbial metabolism intestine.