Diagnosis of superficial esophageal squamous cell carcinoma invasion depth before endoscopic submucosal dissection

• DOI: 10.1093/dote/dox142
• Publication Date: 2017-12-18T15:07:30Z
• Authors: T Mizumoto; T Hiyama; S Oka; N Yorita; K Kuroki; M Kurihara; Y Yoshifuku; Y Sanomura; Y Urabe; K Arihiro; S Tanaka; K Chayama
• Keywords: Submucosa; Endoscopic submucosal dissection; Muscularis mucosae; Lamina propria; Endoscopic ultrasonography; Endoscopic mucosal resection

Endoscopic submucosal dissection (ESD) is a widely accepted procedure for superficial esophageal squamous cell carcinoma (SESCC) limited to the epithelium or lamina propria mucosae (EP/LPM). We aimed compare efficacy of endoscopic ultrasonography (EUS) and magnifying endoscopy with narrow band imaging (ME-NBI) predicting tumor invasion depth in patients SESCC. Specifically, we evaluated ability these examinations distinguish EP/LPM from SESCC invading muscularis submucosa (MM/SM1) more deeply invasive lesions before ESD.We retrospectively analyzed database all who had undergone both EUS ME-NBI pretreatment staging ESD resection at Hiroshima University Hospital between September 2007 June 2015. The clinicopathologic characteristics SESCCs were classified according Japanese Classification Esophageal Cancer.A total 174 included: 124 (71%) EP/LPMs, 35 (20%) MM/SM1s, 15 (9%) mid submucosae (SM2). sensitivity distinguishing MM/SM1 was 72% 83%, respectively. accuracy 70% 82%, Sensitivity significantly higher than those (P = 0.048 P 0.017, respectively).ME-NBI may be useful determination ESD.