Prediction of elevated left ventricular filling pressures in patients with preserved ejection fraction using longitudinal deformation indices of the left ventricle

• DOI: 10.1093/ehjci/jev063
• Publication Date: 2015-04-20T20:41:48Z
• Authors: Suzan Hatipoğlu; Nihal Özdemir; Gamze Babür Güler; Ruken Bengi Bakal; Cetin Geçmen; Özkan Candan; Cem Doğan; Tuba Unkun
• Keywords: Male; Cardiac Catheterization; Diastolic Dysfunction; Stroke Volume; Coronary Artery Disease; Middle Aged; Coronary Angiography; Left Ventricular end Diastolic Pressure; Ventricular Function, Left; Electrocardiography; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Risk Factors; Ventricular Pressure; Left Ventricular Longitudinal Strain; Humans; Speckle Tracking Echocardiography; Female

Estimation of left ventricular (LV) filling pressures is a clinical challenge in patients with preserved ejection fraction (EF). In the present study, we investigated whether LV and atrial longitudinal strain and strain rate (SR) parameters derived by speckle tracking echocardiography (STE) could be used to predict invasively measured LV end-diastolic pressure (LVEDP) in this patient population.LVEDP was measured before coronary angiography was performed in 65 patients with preserved EF (≥50%) referred to elective cardiac catheterization; besides, patients enrolled underwent comprehensive echocardiographic examination before the procedure. In addition to conventional echocardiographic parameters used to evaluate diastolic function LV longitudinal strain and SR, as well as peak atrial longitudinal strain during LV systole, measurements were performed using STE. Only log-diastolic blood pressure, systolic SR, early diastolic SR, SR during isovolumetric relaxation (SRIVR), and mitral early diastolic flow velocity/SRIVR significantly correlated with LVEDP. When age-adjusted stepwise linear regression analysis was performed, SRIVRT values (β= -20.682, t = -3.292; P = 0.002) and log-diastolic blood pressure levels (β= 21.118, t = 3.784; P < 0.001) were independently correlated with LVEDP.When compared with conventional echocardiographic parameters, other longitudinal strain, and SR indices, SRIVRT independently predicted LVEDP in conjunction with log diastolic blood pressure. We suggest that SRIVRT is a valuable parameter to evaluate diastolic function in patients with preserved EF.