Long-term prognostic impact of fasting plasma glucose and myocardial flow reserve beyond other risk factors and heart disease phenotypes

• DOI: 10.1093/ehjimp/qyae070
• Publication Date: 2024-07-13T13:01:04Z
• Authors: Elena Filidei; Chiara Caselli; Luca Menichetti; Michela Poli; Debora Petroni; Letizia Guiducci; Oreste Sorace; Patrizia Pisani; Silvia Pardini; Danilo Bonora; Assuero Giorgetti; Alessia Gimelli; Danilo Neglia
• Keywords: 03 medical and health sciences; 0302 clinical medicine; myocardial blood flow reserve; Short Report; fasting plasma glucose; heart failure; prognosis; coronary artery disease; coronary microcirculation

Cardiometabolic risk factors, including high fasting plasma glucose (hFPG), are emerging prognostic determinants in patients with coronary artery disease (CAD) or heart failure (HF). Coronary microvascular dysfunction might be a comprehensive predictor these patients. The purpose of this study was to assess whether hFPG and global myocardial blood flow (MBF) reserve measured by positron emission tomography (PET), expressing function, predict long-term prognosis beyond other factors presence obstructive CAD left ventricular (LV) associated HF. We retrospectively collected follow-up data 103 (mean age 61 ± 10 years, 74 males) stable chest pain dyspnoea who underwent cardiac PET/computerized angiography. Disease phenotypes included (35%), LV without (43%), none (22%). At multivariable logistic regression analysis, MBF lower than the median value (OR 1.8, 95% CI 1.5-2.2) significantly male gender 3.45, 1.21-9.83) 3.87, 1.17-12.84) among all factors. In 10.9 years (interquartile range 7.8-13.9), 39 (37.8%) died (13.6% death). Cox analyses phenotypes, (HR 1.07, 1.02-1.12), 2.18, 1.02-4.63), depressed 4.47, 1.96-10.18) were independent predictors death (global