Association of epicardial adipose tissue and coronary artery calcium score in patients with atrial fibrillation

• DOI: 10.1093/europace/euac053.300
• Publication Date: 2022-05-19T16:30:45Z
• Authors: S Fernandes; R Ladeiras-Lopes; I Cruz; G Silva; M Silva; P Queiros; S Diaz; A Barros; F Saraiva; R Faria; J Almeida; P Fonseca; N Ferreira; J Primo; R Fontes-Carvalho
• Keywords: Agatston score; Coronary Calcium Score; Epicardial adipose tissue

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Both coronary artery calcium (CAC) and epicardial adipose tissue (EAT) had been implicated in disease (CAD) risk future adverse cardiovascular events. There are scarce data regarding the assessment association EAT volume CAC score (CACS) atrial fibrillation (AF) patients. Purpose To assess between presence severity patients with AF. Methods Retrospective single-centre study including consecutive AF undergoing contrast-enhanced cardiac computed tomography for catheter ablation planning, from 2017 to 2019. Patients known history CAD moderate severe valvular heart were excluded. Baseline clinical demographical collected, as well their risk, based on SCORE (Systematic Coronary Risk Evaluation) system categories. We assessed CACS (Agatston method) analysed association. was defined accumulated visceral pericardium myocardium semi-automatically reconstructed by manually tracing pericardium. split into three groups according CACS: 0, 1-99 ≥100. A logistic regression (LR) analysis performed explore relationship (CACS>0), adjusted age, gender, obesity, diabetes mellitus hypertension. Results total 354 included, a mean age 56 ± 12 years, 66% male 21% persistent CHA2DS2-VASc ≥2 present 130 (37%) most low (n=213, 82%). More than half CACS>0 (n=185, 52%), which 63 (18%) CACS≥100. The 79 39 ml. significant CAC: CACS=0 69 34 ml vs 84 38 ≥100 95 45 (p<0.001) (Fig. 1). After covariate adjustment (LR model R2 = 0.373, p <0.0001), not associated (OR 1.00, 95%CI 1.00 - 1.01, p=0.2) or only higher hypertension 2). Conclusion In our cohort we observed an CACS. Nevertheless, independent predictor classical factors remained significant.