EASY-WPW: a novel ECG-algorithm for easy and reliable localization of manifest accessory pathways in children and adults

• DOI: 10.1093/europace/euac216
• Publication Date: 2022-12-12T13:18:10Z
• Authors: Mustapha El Hamriti; Martin Braun; Stephan Molatta; Guram Imnadze; Moneeb Khalaph; Philipp Lucas; Julia Kathinka No...; Khuraman Isgandarova; Vanessa Sciacca; Thomas Fink; Leonard Bergau; Christian Sohns; Kunihiko Kiuchi; Makoto Nishimori; Christian-Hendrik...; Martin Borlich; Dong-In Shin; Sonia Busch; Denise Guckel; Philipp Sommer
• Keywords: WPW SYNDROME

Abstract Aims Accessory pathway (AP) ablation is a standard procedure for the treatment of Wolff-Parkinson-White syndrome (WPW). Twelve-lead electrocardiogram (ECG)-based delta wave analysis essential predicting sites. Previous algorithms have shown to be complex, time-consuming, and unprecise. We aimed retrospectively develop prospectively validate new, simple ECG-based algorithm considering patients’ heart axis allowing exact localization APs in patients undergoing WPW. Methods results Our multicentre study included 211 single manifest AP due WPW between 2013 2021. The was developed validated by comparing its efficacy two established ones (Pambrun Arruda). All (32 ± 19 years old, 47% female) underwent successful ablation. Prediction AP-localization correct 197 (93%) (sensitivity 92%, specificity 99%, PPV 96%, NPV 99%). particularly useful correctly localizing antero-septal/-lateral 100%) posteroseptal 98%, 92%) proximity tricuspid valve. accuracy EASY-WPW superior compared Pambrun (93% vs. 84%, P = 0.003*) Arruda (94% 75%, < 0.001*). A subgroup children (n 58, 12 4 55% revealed superiority (P reproducibility our excellent (ϰ>0.8; Conclusion novel provides reliable accurate pre-interventional site determination patients. Only steps are necessary locate left-sided AP, three determine right-sided AP.