Arrhythmic risk assessment in genotyped families with arrhythmogenic right ventricular cardiomyopathy

• DOI: 10.1093/europace/euv061
• Publication Date: 2015-03-31T16:21:50Z
• Authors: Alexandros Proton...; Aris Anastasakis; Demosthenes B. Pa...; Loizos Antoniades; Petros Syrris; Apostolos Vouliotis; Christodoulos Ste...; Adalena Tsatsopoulou; William J. McKenna; Nikos Protonotarios
• Keywords: Adult; Aged, 80 and over; Genetic Markers; Chi-Square Distribution; Heredity; Adolescent; Greece; DNA Mutational Analysis; Kaplan-Meier Estimate; Disease-Free Survival; 3. Good health; 03 medical and health sciences; Death, Sudden, Cardiac; 0302 clinical medicine; Echocardiography; Case-Control Studies; Electrocardiography, Ambulatory; Humans; Female; Genetic Predisposition to Disease; Arrhythmogenic Right Ventricular Dysplasia; Genetic Association Studies; Aged

AimsArrhythmogenic right-ventricular cardiomyopathy (ARVC) is a genetically determined disorder, mostly caused by mutations in genes encoding desmosomal proteins. We evaluated phenotype/genotype characteristics to predict the risk for first major arrhythmic event desmosomal-mutation-associated ARVC families.