Vancomycin and ceftriaxone can damage intestinal microbiota and affect the development of the intestinal tract and immune system to different degrees in neonatal mice

• DOI: 10.1093/femspd/ftx104
• Publication Date: 2017-08-21T07:09:18Z
• Authors: Ru Yue Cheng; Ming Li; Shan Shan Li; Miao He; Xiao Hong Yu; Lei Shi; Fang He
• Keywords: Dysbiosis

This study aimed to determine how antibiotic-driven intestinal dysbiosis impairs the development and differentiation of digestive tract immune organs host animals. BALB/C neonatal mice were orally administered ceftriaxone or vancomycin from postnatal day 1 21 sacrificed on 21. The diversity abundance bacteria, morphological changes barrier function tract, splenic CD4+CD25+Foxp3+ T cells investigated. gut microbiota tissue damaged, numbers Ki67-, Muc2- ZO-1-positive significantly decreased in antibiotic treatment groups. Furthermore, administration ceftriaxone, but not vancomycin, led a significant reduction cells. Each caused characteristically influenced regeneration epithelial cells, formation mucus layer tight junctions, Foxp3+ Treg before any clinical side effects observed. potent ability each affect makeup commensal may be key determinant spectrum antibiotics influence health animal, at least partly.