Epigenetic Regulation of Autophagy in Bone Metabolism

• DOI: 10.1093/function/zqae004
• Publication Date: 2024-01-28T04:47:39Z
• Authors: Yazhou Zhang; Qianqian Wang; Hongjia Xue; Yujin Guo; Shanshan Wei; Fengfeng Li; Linqiang Gong; Weiliang Pan; Pei Jiang
• Keywords: 0301 basic medicine; 03 medical and health sciences; Review Article

Abstract The skeletal system is crucial for supporting bodily functions, protecting vital organs, facilitating hematopoiesis, and storing essential minerals. Skeletal homeostasis, which includes aspects such as bone density, structural integrity, regenerative processes, normal function. Autophagy, an intricate intracellular mechanism degrading recycling cellular components, plays a multifaceted role in metabolism. It involves sequestering waste, damaged proteins, organelles within autophagosomes, are then degraded recycled. Autophagy’s impact on health varies depending factors regulation, cell type, environmental cues, physiological context. Despite being traditionally considered cytoplasmic process, autophagy subject to transcriptional epigenetic regulation the nucleus. However, precise influence of including DNA methylation, histone modifications, non-coding RNA expression, fate remains incompletely understood. interplay between modifications adds complexity regulation. This article provides in-depth exploration these two regulatory paradigms, with focus control Such understanding enhances our knowledge metabolism-related disorders offers insights development targeted therapeutic strategies.