Insights into Mus musculus Population Structure across Eurasia Revealed by Whole-Genome Analysis

• DOI: 10.1093/gbe/evac068
• Publication Date: 2022-05-06T11:19:45Z
• Authors: Kazumichi Fujiwara; Yosuke Kawai; Toyoyuki Takada; Toshihiko Shiroishi; Naruya Saitou; Hitoshi Suzuki; Naoki Osada
• Keywords: Subspecies; House mouse; House mice; Divergence (linguistics); Genetic divergence

Abstract For more than 100 years, house mice (Mus musculus) have been used as a key animal model in biomedical research. House are genetically diverse, yet their genetic background at the global level has not fully understood. Previous studies suggested that they originated South Asia and diverged into three major subspecies, almost simultaneously, approximately 110,000–500,000 years ago; however, spread across world with migration of modern humans prehistoric historic times (∼10,000 ago to present day) undergone secondary contact, which complicated landscape wild mice. In this study, we sequenced whole-genome sequences 98 collected from Eurasia, particularly East Asia, Southeast Asia. Although were found consist groups corresponding individuals representing admixtures between subspecies prevalent previously recognized. Furthermore, several samples exhibited an incongruent pattern genealogies mitochondrial autosomal genomes. Using likely retained original components least admixture, estimated timing divergence among subspecies. The time was 187,000–226,000 ago. These results will help us understand diversity on scale, findings be useful future evolutionary involving laboratory established such