Y-Chromosome Structural Diversity in the Bonobo and Chimpanzee Lineages

• DOI: 10.1093/gbe/evw150
• Publication Date: 2016-06-30T00:09:32Z
• Authors: Matthew T. Oetjens; Feichen Shen; Sarah B. Emery; Zhengting Zou; Jeffrey M. Kidd
• Keywords: Bonobo; Pan paniscus; Troglodytes; Amplicon; Subspecies

The male-specific regions of primate Y-chromosomes (MSY) are enriched for multi-copy genes highly expressed in the testis. These located large repetitive sequences arranged as palindromes, inverted-, and tandem repeats termed amplicons. In humans, these have critical roles male fertility essential production sperm. structure human chimpanzee amplicon show remarkable difference relative to remainder genome, a that may be result intense selective pressure on fertility. Four subspecies common chimpanzees undergone extended periods isolation appear early process subspeciation. A recent study found amplicons testis-expressed X-chromosome target hard sweeps, male-fertility Y-chromosome also targets selection. However, little is understood about diversity within across populations. Here, we analyze nine (representing three subspecies: Pan troglodytes schweinfurthii , ellioti verus ) two bonobo ( paniscus) whole-genome assess Y ampliconic copy-number genus. We observe copy number chromosome variable among bonobos, identify several lineage-specific patterns, including azoospermia candidates RBMY DAZ . detect recurrent switchpoints change along tracts populations, which localized genome instability or forces.